Clinical Trials

Since Provocholine is a diagnostic agent, there is great value to including methacholine challenge testing as part of clinical trial protocols.  It can have a variety of applications depending on the question that is being asked.

Methapharm has experience providing technical support for clinical trials using Provocholine in the following areas:

  • Study inclusion/exclusion criteria
  • Bioequivalence
  • Quantifying a response to investigational medications
  • Comparing inhaler devices
  • Epidemiological studies
  • Specific atopies (allergies)
  • Consumer product evaluation

The FDA have issued two guidance’s where methacholine challenge testing is discussed specifically when used inclinical trials:

Research

Research on asthma and other respiratory conditions has evolved over the years. Provocholine is frequently used as the primary outcome or in conjunction with other drugs/procedures. In recent years, research using Provocholine has been effectively used to rule out asthma in patients, especially children, given that family history and other variables are taken into consideration.

Looking to for relevant publications on using methacholine challenge testing?Please visit the publications(linked to that page) page.

If you would like more information about using Provocholine in a clinical trial or for research please Contact Us (linked to contact us page)