1) Crapo RO, Casaburi R, Coates AL, et al. Guidelines for methacholine and exercise challenge testing. Am J Resp Crit Care Med 200; 161(1):309-329.
2) Wanger, JS, Ikle DN, Irvin CG. Airway responses to a diluent used in the methacholine challenge test. Ann Allergy Asthma Immunol 2001;86:277-282.
3) Martin RJ, Wanger JS, Irvin CG, et al. Methacholine challenge testing; safety of low starting FEV1. Chest 1997;112:53-56.
4) Ramsdell JW, Nachtwey F, Moser KM. Bronchial hyperreactivity in chronic obstructive bronchitis. Am Rev Respir Dis 1982; 126:829-32.
5) ATS Pulmonary Function Laboratory Management and Procedure Manual. Chapter 12. 2005.
6) Goldstein, MF, Pacana SM, Dvorin DJ, et al. Retrospective analyses of methacholine inhalation challenges. Chest 1994; 105:1082-88.
7) Pratter, MR, Irwin RS. Usefulness and safety of pharmacologic Bronchoprovocation challenge in evaluating patients with normal spirometric tests who are suspected of having asthma. Chest 1988; 93:898-900.
8) Townley RG, Bewtra AK, Nair NM, et al. Methacholine inhalation challenge studies. J Allergy Clin Immunol 1979; 64:569-74.
9) Pratter, MR, Irwin RS. The clinical value of pharmacologic bronchoprovocation challenge. Chest 1984; 85:260-65.
10) Pratter MR, Bartter TC, Dubois J. Bronchodilator reversal of bronchospasm and symptoms incurred during methacholine Bronchoprovocation challenge. Documentation of safety and time course. Chest 1993;104:1342-1345.
11) Tashkin, DP, Altose MD, Bleecker, ER, et al. The Lung Health Study: Airway responsivemess to inhaled methacholine in smokers with mild to moderate airfl ow limitation. Am Rev Respir Dis 1992; 145:301-310.
12) Tashkin, DP, Altose MD, Connett JE, et al. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. Am Rev Respir Dis 1996;153:1802-11.

For more information, please contact us.