The Importance of Objective Testing
Clinical studies have suggested that a substantial proportion (approx. 30%) of patients may be overdiagnosed with asthma.
Asthma Diagnosis may present a challenge
Asthma is a heterogeneous disease that can be deceptively difficult to diagnose. In the absence of objective testing, patient
history and symptoms such as wheezing and cough may not be definitive clinical markers of asthma. Further, other causes of
airway obstruction leading to wheezing include conditions such as COPD (e.g., chronic bronchitis or emphysema), congestive
heart failure, pulmonary embolism, mechanical obstruction of the airways (benign and malignant tumors), pulmonary infiltration
with eosinophilia, cough secondary to drugs (e.g., angiotensin-converting enzyme (ACE) inhibitors), or vocal cord dysfunction.2
Lastly, methacholine challenge tests may also be helpful in diagnosing cough variant asthma (a chronic cough which is the
principal — or only — manifestation of asthma) especially in young children.
Why Provocholine is the agent of choice for bronchoprovocation challenge testing
Provocholine is an FDA approved Rx drug and, as such, is subject to the FDA’s stringent regulations on drug purity and safety.
Provocholine is precision weighed to ensure the accuracy of the 100 mg dose. As the methacholine challenge test is a dose response test, accuracy of the dose is essential. As an FDA approved drug, Provocholine is manufactured under strict cGMP conditions in inspected facilities. It is manufactured in a highly controlled environment to address the highly hygroscopic nature of the drug product.
Provocholine is the only FDA-approved methacholine chloride for human use. Each vial is labeled with the product NDC, the lot number, and an expiry date.
Provocholine is packaged in airtight vials to ensure that the quality and potency of the drug is not compromised by exposure to air. A green flip-off seal with grey stopper guarantees ease of use.
The Methapharm Team is here to support you.